The global perfusion systems market was valued at $79.7mn in 2016 and is anticipated to reach over $148.4mn by 2024.The perfusion systems market is anticipated to witness lucrative growth due to the growing prevalence of chronic diseases, rising demand for organ transplantation, growing geriatric population and technological advancements in organ preservation and transportation.
The rise in kidney failure due to obesity, diabetes, and high blood pressure is amongst the key factors driving the demand for transplantation. The American Kidney Fund estimates that 44% of all new kidney failure cases are due to diabetes, and 28.4% cases are due to high blood pressure. In 2015, the International Diabetes Federation (IDF) estimated that globally, over 400 million adults had diabetes and by 2040, more than 642 million adults are expected to suffer from diabetes. The growing prevalence of obesity, diabetes and hypertension are anticipated to strongly drive the demand for perfusion systems over the forecast period.
The waiting list for organ transplantation is growing rapidly, as more number of people are suffering from end-stage cardiovascular and kidney diseases. The lack of proper preservation technologies is resulting in high failure rate and wastage of resources. Traditionally, techniques such as Static Cold Storage (SCS) and Machine Perfusion (MP) were used for organ preservation. Moreover, to overcome the inefficiencies in preserving high-risk organs, Normothermic Machine Perfusion (NMP) is being adopted widely.
North America has a significantly higher base of geriatric population, suffering from various end-stage chronic conditions. The shortage of organ donors and inefficiency in preservation are a major concern to the government and healthcare providers. The Administration of Aging (AoA) estimates in the U.S., suggest that there are over 46.2 million people aged 65 and above, and majority of these people suffer from at least one chronic disease which eventually leads to organ failure or organ damage. The rise in demand for organ transplantation is anticipated to reinforce market growth over the forecast period positively.
“Optimal Price Point (OPP) for Technology and Products”
Estimated Average perfusion system cost – $ xx globally. However, with improving access and availability of options, OPP and range of acceptable Prices (RAP) are going to change. We at Ameri Research continuously track these prices with our proprietary pricing model. The prices of these systems are in the range of USD 10,000 to USD 100,000 and above depending on the technology, lifespan of the system and ability to preserve high-risk organs. The value or return on investment of these products is calculated based on an average lifespan of 10 years, which include the cost of consumables, accessories maintenance costs and the number of organs serviced during the period.
Perfusion Systems Market by “Technology”
Based on Technology, the market is categorized as hypothermic and normothermic. The hypothermic machine perfusion technology is used since the 1960’s and its major application areas include neurosurgery, cardiovascular surgery, and trauma care. The process involves the lowering of organ temperature to arrest the metabolic activities, decrease oxygen and substrate demand by the tissues and cells. Moreover, hypothermic machine perfusion of liver enables the continuous flow of metabolic substrates, antioxidants, and helps in flushing out toxins, cytokines and proteins from the liver.
However, normothermic machine perfusion is expected to emerge as the fastest growing due to its ability to overcome the problems faced due to cold storage for a longer duration. This technology can be used in in-situ and ex-situ perfusion techniques, and the results are more satisfactory compared to the hypothermic preservation. The warm blood preservation technique is gaining high demand for kidney and liver transplantation, and several R&D initiatives are in progress to extend the benefits of this technology for other organ transplantation.
Perfusion Systems Market by “Organ Type”
Based on the organ type, the market is segmented as kidney, heart, lungs, liver and others. Each organ requires specific preservation environment, and therefore specialized systems are used for each organ type. In 2016, kidney transplantation accounted for the majority share due to the high prevalence of chronic kidney failure. Few products which are used for machine perfusion of kidneys include WAVES RM3 by Waters Medical Systems and LifePort Kidney Transporter by Organ Recovery Systems Inc.
The growing prevalence of heart failure is expected to drive the future growth. The heart segment is expected to register the highest CAGR of over 8.2% over the forecast period.
In 2016, North America held the maximum share due to the high disease burden, well-developed reimbursement framework, presence of advanced technology and a large number of patients registered for the organ transplantation. As per the latest data (May 21st 2017) by U.S. Organ Procurement and Transplantation Network, there are 117,960 patients who require an organ transplantation, and 76,016 people are on the active waiting list. Moreover, there were 11,061 transplantation procedures performed, however on an average 22 people die each die while waiting to receive a transplant. The chances of a heart failure and kidney failure increases drastically with the increase in age, and on an average every 10 minutes a new patient is added to the national transplant waiting list.
Asia Pacific is expected to outperform other regions by registering the fastest growth over the forecast period. The high population in the region, growing prevalence of chronic diseases and rising awareness about organ donation and transplantation are expected to drive the market growth. For instance, India is now the leading nation with the highest number of diabetic patients, with more than 69.2 million patients diagnosed. The high prevalence of diabetes is expected to increase heart failure and kidney failure rates significantly. Moreover, the government initiatives to promote national and regional organ transplantation networks is expected to reinforce growth prospects over the forecast period.
“Competitive Landscape” and “Merger & Acquisition Insights”
The perfusion systems market is dominated by players such as Organ Assist B.V.; TransMedics, Inc.; OrganOx Limited; Organ Transport Systems; Paragonix Technologies, Inc.; Organ Recovery Systems; XVIVO Perfusion AB; Waters Medical Systems; and Bridge to Life Ltd. Most of the players operate exclusively in therapy areas such as Heart, kidney or liver, and are looking to expand through the acquisition route to bolster their portfolio and regional presence.
Perfusion Systems Market by Technology, (Revenue, Million, 2014 – 2024)
Perfusion Systems Market by Organ Type, (Revenue, USD Million, 2014 – 2024)
Perfusion Systems Market Regional Outlook, (Revenue, USD Million, 20124- 2024)
Middle East and Africa
- South Africa
- Saudi Arabia